I just realized that DC doesn't really have an ultimate female big bad in decent place. At least not in a proportional amount. Darkseid, Mordru, Ra's Al Ghul, Vandal Savage, Mongul, Luthor, Black Mask,Penguin, Falcone, Thorne, Whale, Black Adam. It's a sausage fest.
The closest thing in the role turned out to be Talia, a Femme Fatale who was pretending to be a damsel in danger but turned out to be quite a vamp/baroness/dragon lady. Morgaine and Queen Bee are a close second but they don't get many great stories either. Paula von Gunther, Cheetah, Roulette and Emerald Empress should get there. Any others?