Hmm yeah!
Betty was a bad-ass even before she became a She-Hulk.
I do not see why a counterpart of 616 Betty Ross R.i.p. 1962-2015 cannot appear on the new mainstream marvel earth post Secret Wars and become the all-new Red She-Hulk. Also, if 616 Bruce Banner survives Secret Wars than I hope he will be mourning 616 Betty and 616 Rick Jones R.i.p. 1962-2015.
The rebooted Marvel universe after Secret Wars will eventually have to have Betty in it (unless Universal somehow owns the film rights to the character which given Talbot being in Agents of SHIELD seems unlikely), the issue will come whether or she will be Red-She Hulk or not.