Not exactly.
Mary Jane by Kirsten Dunst was a bigger deal than other superhero love interests that came before.
You look at Superman, Margot Kidder was the love interest for Superman 1, 2, but then she was relegated in the later movies. In the case of Batman, he had a new love interest in all of his films up to that point.
But for Spider-Man, Kirsten Dunst's Mary Jane was central for the entire trilogy, there was never anyone else. Those movies were marketed and sold as a superhero romance.
As Kirsten Dunst said on the poster for Spider-Man 2, it was her and Spider-Man.
What she meant was that it was her and Spider-Man, and not her and Tobey Maguire. She was the performer without the mask who got to command the movie poster.