Scourge the Hedgehog takes on Kara Zor-El in his Super form.
Scenario A) post-Crisis Supergirl.
Scenario B) post-Crisis Kara Zor-L.
Scenario C) New 52 Supergirl.
Scenario D) Live Action Supergirl.
Location: Moebius (Mobius' mirror universe counterpart).
The only reason why I didn't use pre-Crisis Supergirl is because that would be a total godstomp.