On a relevant point, someone else mentioned that the chipped horns + missing tooth were some of the branching points of this timeline from the other timeline. I've wondered about that myself after I saw the pictures, but I don't feel like it's a large enough change to affect the final outcome, in and of itself (many small changes might add up to large change, however). Mostly because it seems to easy.
As for Al reminding us that everyone King!Loki said when he had a truth sword through his chest was true (well, emphasizing that fact)--I'm kinda torn in my opinion about what that means. On the one hand, didn't he say we were supposed to wrap up the King!Loki stuff in issue 12? On the other hand, it reminded me a lot about "predestination", which ties into Freya wanting a certain future (as well as Al mentioning she'd show up in issue 15), and the fact that the next arc is supposedly "mythic" in nature. Furthermore, Cul
is back (he says hi). So maybe they're facing another Ragnarok. Again. Or something having to do with the repercussions of ending that cycle. But I don't know how they could get King!Loki so easily if that were the case.