I have heard the argument that Marvel lacks sympathetic villains at this point, that villains are just evil nowadays as not to distract from the hero vs. hero fights and make heroes who have become jerks seem sympathetic in comparison. Is that a fair assessment? I have heard some people complain that say Mystique has become a one dimensional evil psychopath recently and all her sympathetic traits have been ignored, for example.
I think a big problem is, sometimes writers have a sympathetic villain do something so evil, that it makes them seem totally unsympathetic. Like Kingpin's child kidnapping plot from Man Without Fear (which I'm not sure is in canon or not), Magneto trying to commit genocide a couple of times and Doom's actions in Unthinkable.
It seems like writers have an easier time writing a pure evil villain consistently then they do with a sympathetic one, I'm not sure how often Red Skull or Bullseye have been written out of character.