Why would the comics be a whole other story in finding a place for Ava to fit in though?The slow trickle of info about the potential Black Widow movie project is gradually getting me excited, which is probably a bad idea since it hasn't been acknowledged yet, and it could get dropped like the Lionsgate movie or Inhumans.
And, just like when people were suggesting a movie all those other times (read: after every other movie she was in), naysayers are crawling out of the woodwork with a lot of the same arguments. I think the worst one that I keep seeing in the comments sections is that Scarlett Johansson is "too old" now. Aside from being a hilarious example of public misogyny that we could possibly think of a 33-year-old actress as "too old" (never mind all of the older actors in the MCU who are in the middle of continuing franchises), it's not even a downside to have an aged Natasha in a movie. Her age was central to the plot of Itsy-Bitsy Spider, and formed part of the contrast with Yelena. I think Devin Grayson even said that she wished J.G. Jones had drawn Natasha to look older.
Yeah, the books themselves don't fit into the 616 at all, and the tie-in comics seem just to function as extensions of the books. It's not out of the question at all to see elements of them adapted into Natasha's stories, but the obstacle is to find a writer that would have an angle where Ava would fit. The addition of Red Widow as a POV character makes sense if you're trying to write a Young Adult novel about Natasha, who isn't the type of character with a lot of typical YA storylines. But the comics are a different story. It might be more likely that a teen team like the Champions would introduce her, since she fits into that space more easily.