Well, it's a toss up. Because DC has done books where the whole thing was released at once as a trade, and it's gone on the best seller list.
I honestly thing this will be the way forward for comics because the mentality behind a lot of singles is "how long can we string this out" where as OGN would be actual planning and actual arcs. So the writing would be better. When a single comic sucks people just dismiss it as "well its only $5" or however much a single costs?