For people that have been reading Spider-Man 2099, this issue was ridiculously awesome.
Here's a quick run-down of what you need to know from that book, as it seems that very few people have been reading both:
Miguel O'Hare is Spider-Man in the year 2099. As of the start of his new series, he has been transported back into time to 2014.
Miguel's father (Tyler Stone) is the head of the biggest, most evil mega-corporation in 2099, named Alchemax. In 2014, Alchemax is still growing in power, and Miguel's grandfather, Tiberius Stone, is in charge in our era.
As the series progresses, Miguel gets a job at Alchemax. Because he doesn't want to alter the future by having his name in the company database, he uses a fake name (Mike O'Mara).
That's basically all you need to know. In ANXF #20, we learn that Harrison Snow is from the future and has been a friend of Spider-Man 2099 this whole time, and that he's a "good guy" who is using his company Serval to take down the evil empire of Alchemax.
IMPLICATIONS: I don't recall if Spider-Man 2099 is working as a hired bodyguard at Alchemax yet, but it was a plot direction that PAD was moving towards for certain. This means that we will probably get to see X-Factor fight Spider-Man 2099 in the near future, as one company head attempts to attack or sabotage the other.
*I haven't read PAD's Hulk: Future Imperfect, but I'm willing to bet that the green guy ruling in the future is Maestro.