The Spectacular Spider Man book of my youth ( ouch), focused on mostly the classic supporting cast and Spidey's more obscure villans.
In other words all the stuff Dan Slott has little intrest in.
You could easily fit a second Spider Man book that deals with all the stuff that the main book doesn't do at all like deal with the Lightmasters Mirages and the Sinister Sixes.
...Or check in on the Liz Allens, the Hobie Browns and the Betty Brants.