I think Miles would be awesome, and would personally make me a lot more excited as it'd be a pretty clear statement that they're wanting to do something new. You could still do it without a big origin story, even borrow some Parker-centric peripheral elements like your Daily Bugles and Flash Thompsons and what have you, but we've heard they're looking to do high school age, focusing more on the conflict between personal life and superhero life than a romantic story, and Bendis' Miles story so far is a perfect model for that. Very much in the spirit of what made Lee and Ditko's Spidey the character we love, but totally contemporary in execution. (Not just superficially, but in tone, the dialogue.. some of Bendis' best stuff for sure. The right screenwriter/director(s) could make an amazing movie in that vein...)