We had this thread once upon a time and I enjoyed it. So I thought I'd start a new one. Here's a few examples to get things started.
Deadwood:
Cyclops - Seth Bullock
Wolverine - Al Swearengen
Rogue - Trixie
Emma Frost - Alma Garret
Jean Grey - Martha Bullock
Sabertooth - Cy Tolliver
Iceman - Sol Star
Toad - E.B. Farnum
Sebastian Shaw - George Hearst
Colossus - Dan Dority
Beast - Merrick
Game of Thrones:
Beast - Tyrion Lannister
Cannonball - Jon Snow
Mystique - Queen Cercei
Kitty Pryde - Arya Stark
Wolverine - Sandor 'The Hound' Clegane
Sebastian Shaw - Tywin Lannister
Cyclops - Stannis Baratheon
Rogue - Ygritte
Emma Frost - Margaery Tyrell
Sabertooth - Gregor "the Mountain" Clegane
Gambit - Daario Naharis
Xavier - Maester Luwin