Mewtwo is dropped into the universe of Neon Genesis Evangelion and is told that he can only escape if he prevents Instrumentality from occurring. To do this, Mewtwo must not only destroy the Evas but also Adam and Lilith in Terminal Dogma.
NERV detects Mewtwo and they think that Mewtwo is an angel. NERV sends out the Evangelions to deal with Mewtwo.
Can Mewtwo defeat NERV and prevent Instrumentality?
This is animé Mewtwo from the First Movie and Mewtwo Returns.