Earlier today, Bleeding Cool released an article that hinted at what would happen to the X-men after Secret Wars. And no, they're not being canceled or retconned out of existence. They're still going to be a part of the 616 Marvel universe. Axel Alonso has already confirmed that. However, if this rumor is true, that role won't be on the same planet.
This would be a pretty extreme, but creative way to separate mutants from Inhumans. By making it so mutants can't live on Earth anymore, it creates a whole new set of challenges for the X-men to overcome. And as it turns out, there may already be a world for them to inhabit. In Uncanny Avengers, Remender established Counter-Earth. It's basically a carbon copy of Earth, but it's always on the opposite side of the sun. It has the same atmosphere, climate, etc. It would be a perfect place for mutants to relocate if someone could take care of the High Evolutionary.
I can see this upsetting some and I know it's going to feed into the conspiracy theories that Marvel wants to spite the X-men over the movie rights. However, I really like this idea. I think it establishes a very different dynamic for the X-men to deal with. They're still in the same universe. They can still interact with the Avengers. They can still participate in crossovers. They're not completely isolated, but they can essentially function on their own. I have a feeling this is going to seriously divide many X-men fans, but I'm going to try and be a bit more optimistic if this turns out to be true. The X-men have already gone on a number of space adventured. This just seems like a logical step.