Oh I agree. This certainly is not the first time Peter has decided to give up being Spider-Man for personal reasons. And the Spider-Man 2 example goes to exactly the point I was getting at: whenever Peter Parker decides to forgo being Spider-Man in order have a life of his own, it winds up being a costly mistake which forces him back into the webs again. I believe Dan Slott in past interviews with EW teased we can expect Kraven the Hunter to show up at some point, and if that's the case, I imagine he or some other enemies will try to target Peter through his family.