This is a thinly disguised attempt to mesh the TV series with current 616 continuity Quake and Skye. Even the Hyde character is being meshed the same way. There is some flashback to early Marvel comics of Hyde fights with Thor and DD, as Hyde tries to deny any responsibility for Quakes powers, but he is found out.
spoilers:end of spoilers
Hyde is hold up in. castle in Portugal, and Quake is sent in with a team to capture Hyde. Not hey are successful and return Hyde to a captured Anim Zola biology lab for Dr Calvin Zabo to create a cure for Daisy's condition, as her Quake powers are cracking her bones. Zabo succeeds and gives Daisty the cure, but also gives himself the Hyde Serum to counter the antidote SHIELD used on him. Coulson gets the serum too and Hydes out fighting Zabo until Daisy regains her senses from the cure and Quakes Zabo into a hole. They mention they have given Daisy the Knicks name of Skye because she spends most of her time in space now.
The stories in this are thinly veiled continuity in the 616, but interesting enough for me to be picking up books with Simmons and Fitz in them. I like that pairing so much, that I overlook the difficulty with meshing the comic verse with the movie verse, that shouldn't be possible.
And yet the connection between Quake and Hyde goes as far back as Bendis, I think, so for Waid to be trying to tell that story in this setting was a good attempt, to my mind.
All these series' finishing up stories before the MU is destroyed, can tell the most bizarre stories they possibly can, because what the hey, it all gets wiped away with Secret Wars anyway.