This week we got the announcement of the new actor playing Peter / Spider-man, as well the as the director, of the next Spider-man films (which will presumably have sequels).
So the script is probably in its final stages, additional casting will commence and camera will probably start to roll on this thing next year.
What villains should be featured this time around? Pick multiple ones that you think deserve to get the spotlight. I also included "Other" if you want to write in The Spot.