I could see it work between Jennifer and Peter. It takes a good creative team to make it happen in a manner that creates a compelling story that future writers will want to follow. And there is a good story that can bind Jennifer and Peter together as close friends that has never been portrayed anywhere else. And it's not fan fiction. Marvel has a lot of story paths that ties Spider-Man's world to the She-Hulk, as well as Peter's teen years where he might have met Jennifer as a classmate.
It dawns upon me as to how Spider-Man is a reserve member of both The Avengers and Fantastic Four, yet no one wants to have Peter work alongside Jennifer...