One of my favourite literary/comic book/anime villains is the character Light from 'Death Note'. He's hands down one of the most vile, sociopathic, devious, predatory and manipulative characters I have seen. I would love to see more villains along that line (or Iago from Othello) in comic books. But I don't think that that there are many writers in comic books who have the talent to create such a villain.