Best non batman related female super villains?

[foxley]

Just sticking with DC, if you take Batman's gallery out of the running (and really, that's just 3 anyways: Poison Ivy, Harley Quinn, and Catwoman). . then next best is going to be Wonder Woman:

Circe
Cheetah
Giganta
Silver Swan

Flash has an incredible Rogues Gallery, but really his only villainess is Golden Glider -- and tho I love that character, she's kind of lame.
Superman really only has Silver Banshee who's decent.

so yeah.. . the answer would be Wonder Woman's villains.

Flash had a few later female additions to his rogues gallery: Magenta, Blacksmith, and Peekaboo off the top of my head.

[foxley]

Mist from James Robinson's Starman.

[bert]

Point taken. Just remembered the Queen of Fables from Mark Waid's run on JLA.

co-created by Gail Simone.

[Mister Mets]

Dark Phoenix.

[Lorendiac]

Depending on your tastes, there are great villainesses to be found all over the comic spectrum

Will Eisner's set the standard for femme fatales in The Spirit (The Octopus, Silk Satin, and P'Gell among others)

The mysterious villain known as "The Octopus" was not a woman. Or at least he always was disguised as one man or another (but always wearing some distinctive gloves) whenever he met The Spirit, which I admit might not be the same thing as "he was really a man and a strip-search would have proved it!" But the point is that I don't recall a single hint that "he" was actually a female cross-dresser. I suspect you were getting him mixed up with one of the other colorfully-named characters from The Spirit's Golden Age stories.

But getting back to the main point of the thread . . . some of my personal favorite non-Batman-connected supervillainesses include:

Marvel's version of Morgan Le Fey.

Dark Phoenix.

DC's first Terra (Tara Markov who died in "The Judas Contract").

Marvel's Anarchy (no relation to DC's "Anarky," aka Lonnie Machin).

Emerald Empress.

Selene/Black Queen.

Marvel's Nanny (the one who had a minion called Orphanmaker).

Blackfire.

Lady Shiva.

Oh yes, and I'm rather fond of the Pre-Crisis version of Wonder Woman's old sparring partner "Dr. Cyber!"

[Ghost Rider TheHellfireDemon]

I agree with WW
Circe
Damn how freakin underrated. She believes the amazons mission for peace with a combat society is a farce. She should be a wrecking ball in the dc universe, and a damn powerful magic user.
Cheetah(barbaraminerva) She is a dark indiana jones, also cursed by her gods so being a utter opposite of Wonder Woman. Plus with her jealousy of Wonder Woman she is a highly destructive foe.
Silver Swan
Devestation

[saul_on_the_road_to_damascus]

Typhoid Mary

[ed2962]

If we can include anime characters then I say Balalaika from Black Lagoon

[buffalorock]

Fatality I think is a great Green Lantern villainess. Star Sapphire used to be as well but she is now a hero too.