I like both Silk and Spider-Gwen. But (forgive me, Pav) the first is my favorite of the two. I find Stacey Lee's art on Silk just superb (it's what got me into the series) and the script Thompson is handling points to a long plan. Given his precious work, I suspect it will be a well-crafted one.
In contrast, I get the impression that Spider-Gwen is still kinda experimenting in the story department; however that may be part of its charm: as Pav (and other users here) point out, it is full of potential, its lack of barriers and possibility of reinventing astonishing. It just needs to use it and deliver a memorable story. Which could be coming, but I hardly know Jason Latour's work.
(Robbi Rodrigue's kinetic style is fun, alas, sometimes too overcrowded for my taste and I'm not too enamored with Rico Renzi's colors - both are still great artists, no disrespect. But I find Lee's lines and Ian Herring more pleasant. Serene-inducing even).
I'm with Highland Chicken and Venomous Mask in recommending you 2099, Venom and the recent Scarlet Spider. This last one specially as Kaine's adventures are both my favorites and were written by a name you may recognize from X-23's adventures: Chist Yost.
That said, by the virtue and nature of a supporting character there, the action sometimes intrudes into the territory of the supernatural - specially during two issues - but they don't stray too far into it, quickly bouncing back to the street-level and street-based solutions as Kaine is not really Stephen Strange - his world is of concrete, breaking stuff and stealing money from criminals. Even when given occasional supernatural strength.
The exceptions are the latter part of the arcs In the Midst of Wolves, the admittedly-not-so-good Minimum Carnage crossover (where it plays with the Microverse) and a small fight in the last issues that is mostly the after-effect of one of the most hilarious scenes I have encountered. All the other antagonists and fights are decidedly more "normal".
You can take a peek and see others people's opinions on it in the following thread. I include some short descriptions (and minor spoilers) if you are interested
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Scarlet blood drops on the stone - Kaine the Scarlet Spider and Hummingbird appreciation
http://community.comicbookresources....9-appreciation