Orphaned means that a follow up volume of a multi volume set will never be released. Bendis has only had a Volume 2 for his Daredevil run. Both Ultimate Spiderman and New Avengers never saw a volume 2 and at this point probably never will. Powers is still recent enough it could happen, and the same with Guardians, but because of the other examples it is possible they won't. As always who knows with Marvel.
Edit: Just looked and saw Powers was a 2015 release so the possibility of Vol. 2 is pretty iffy at this point IMO.