I have no horse in this race since I don't like the artist or the stories so I won't get this book but I always thought Marvel managed to avoid this problem in the past before and it was mostly an issue with DC collections.
As for personal preference flow is everything for me. I skip anything unnecessary in a heartbeat and I actually kinda lukewarm now on the epic collections because they collect loads of extra stuff I would never read like ashcan issues or inconsequential annuals and crossover appearances more than omnibuses tend to do.