Mayuri and Aizen both absolutely deserve all kinds of asswhuppings. But the restraints on Aizen are actually really good at keeping him locked down, I mean he could only escape the chair once Yhwach blasted him out of it after all, and Mayuri was never after godhood, he's just terrifyingly curious and doesn't give a shit about other people.
Anyway... GoD Toppo vs Sosuke Aizen, Mayuri Kurotsuchi and Ororchimaru.