Ok Marvel experts, I need to know who is the top female supervillian from the Marvel Universe. The female analog to Dr Doom, Apocalypse, Kang.
This isn't a simple question. This question can be answered in several levels:

Is she the most powerful/smarter/resouceful?
Is she the most feared among the marvel characters?
Is she the most famous in her ranks beyond the comics world?
Which was her greatest feat?
Who can fullfill these requirements?