I don't think Donna has been changed all that dramatically in comparison to the whole of the New 52 when you consider:
- Lady Hawk(Shayera Hol formerly Hawkwoman pre-New 52) was a Thanagarian militant extremist who tried to kill her former love Hawkman.
- Green Lantern(Alan Scott) is now a homosexual and gets his powers from the Green instead of a lantern fueled by a science/magic combo made by the Guardians of the Universe.
- Flash(Jay Garrick) received his powers from the Roman god Mercury instead of a hard water accident.
- Lobo, while still a bounty hunter, has a very GQ look.
- Sargon the Sorcerer is now a woman and a complete villain.
- The android Red Tornado now has a female body and houses the mind of the Earth 2 Lois Lane.
- Lex Luthor and Captain Cold are full-fledged members of the Justice League.
Need I go on?