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This is from the issue of deadpool where he roasts the Marvel Universe.
it was one of the last or last issue IIRC
i thought it was just a joke about Sue and Namor making their own plans without Reed's knowledge.
after the events of SW has unfolded it make pretty clear sense now! spoiler alert!
reed and sue have 'retired' while namor is 'missing'
share the panels that foreshadow events and developments here!