Matt Wilson of the Comics Alliance has a piece on Ditko.
It is interesting how Spider-Man was very different from the usual superhero under Ditko, and then kinda got more typical under Romita (which is also when the book became Marvel's bestseller.)Awkwardness was a key component of Ditko’s Spidey. It’s easy to overlook because Ditko co-created him, but Ditko’s Spider-Man was weird. He appeared on-panel in impossible, contorted positions. Peter Parker wore huge glasses and bad sweater-vests.
And it wasn’t just him. Aunt May looked like she would crumble into dust any second. Doc Ock looked like a goblin. J. Jonah Jameson had a full-on Hitler mustache, and the Osborns had hair that looked like an optical illusion. Ditko was unafraid to make characters in his superhero comic look a little repulsive, an idea future artists would tamp down on or full-on reject for quite a few years after Ditko left the book.
Ditko’s Spider-Man was also a clear underdog. Though he’d get more muscular in the decades to come, Ditko’s Spider-Man vacillated between being an athletic, but still fairly small superhero, and being an out-and-out beanpole. He was visibly smaller than most of the other kids he went to high school with, let alone the villains he fought and the other superheroes he occasionally rubbed elbows with.