This pic might come from the cover of Amazing Spider-Man #29 so,
Spoilers (maybe)
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Looks like Otto might be going up against Pete and to be honest I think Peter is way over matched.
1) Otto always held his own with what was a below average body and now he's got a "Spider-Man" body.
2) Complete with Octo sense.
3) Tech vs. Tech I'm giving Ock the edge because not only is he familiar with Parker technology he doesn't limit himself to stun settings.
4) Octavius knows Sider-Man's identity.
5) Spidey doesn't have SHIELD to help him.
6) Otto has Hydra.
7) Otto has the Hydra Avengers.
8) Otto is really, really pissed (I mean more than usual).
Peter's only real advantage is Anna and whether Otto is still carrying a torch for her.