Interesting to see Regent and Maker were put into a big hole as part of stopping crime before it happens. But not Thanos and Norman Osborn, or Red Skull?
It would have been nice to see Red Skull and Thanos could have been holed. But I think Red Skull was seen buying genome weapons from Baron Strucker in one ANAD story, so I think he's back in circulation, Xaviers brain and all.