First off, continuity is off the table. The multiversity is supposed to make it so that anything can and will exist. So it's up to you, for your choosing. Sensational comics can be your main Wonder Woman.
Regarding the new 52, WW#0-35 by Azzarello and Chiang. It doesn't mention anything lesbian but an amazon is having a crush on Diana, and it seems that there isn't any shame involved. So I figure -in that story that- they're okay with women loving women.
While the run doesn't go into transgender-territory, it did at least brings some Agender-theory to the table. Constantly putting gender to question, if it's about nurture or nature, while also going into duality (for example suggesting that Zeus is both a mother as well as a father.).
It wouldn't surprise me if Grant Morrison's Earth 1 Wonder Woman book will touch upon transgender men and fems, lesbians and such. I think his positivity would gel well LBGT stuff in a Wonder Woman story