I sometimes wonder how much of the past 15 years of X-men comics would ever get picked up for movies, cartoons or video games with the X-men?
Considering that these adaptions have a massive free pass on how they interpret characters and storylines from the comics, it makes me think that if House of M and Decimation was ever adapted into a movie it would be handled like Infinity War and Endgame.
One ends in the big shock, in this case 99% of all mutants losing their powers, the other explores the post "shock" event world while the heros try to find a way to resolve it. Because i can imagine movie goers would mainly care about the horrible event to get resolved in the follow up storyline, rather than being willing to keep watching movie after movie of it getting worse. Having a lower tollerance for missery storylines being dragged out for too long than longtime comic readers.
Interesting enough i can imagine a movie version would also be more willing to actualy depower prominent power players, since it wouldn't be meant forever.
Of course with the movies there would likely not be an agenda by the editor in chief to reduce the importance of the X-men and especialy mutants in the marvel universe, because of personal feelings regarding them. So there would be that too.