I can imagine a universe in which the Fantastic Four are replaced by Henry Pym, Janet Van Dyne, Erik Josten, and Eric O'Grady. They could be physically altered by entering the Kosmos Dimension. A slightly different Ultron could replace Doom. Doc Nemesis could replace Wizard. Maria Trovayna or Monica Rappacini make decent surrogates for Alyssa Moy. There's room for Rita Demara as well. Bill Foster would be reimagined as this version of the FF's SHIELD liaison and fellow scientist. Scott is Cross's version of Trapster. His daughter would eventually be taken in by the FF in their Future Foundation.