Earth-1234
In this universe May Parker and Otto Octavius got married but when May found out that Otto was going to do something horrible. She tried to stop him but Otto ended up accidently killing her. Otto made it look like someone else did it but Peter Parker saw right through it and fought him until he killed Otto after that Peter stopped being Peter Parker and was just 'Black Suit' Spider-Man who took a very aggressive approach to crime fighting. When Otto died his death was blamed on The Punisher who didn't like that at all and went to hunt down Spider-Man. Along the way Frank Castle ended up killing some Spider-Man's villains including Rhino, Shocker, and Eddie Brock whos symbiote then bonded itself to Frank, becoming Venisher (or Puninom).