Now that the Black Cat is a super villain, I feel that Jessica Drew has the best chance of begin Peter's ally and companion in a reoccurring guest spot, along with a few others. One of the reasons to keep Peter single is because he could have gotten more intimate with Felicia Hardy(Pre-OMD), as well as Betty Brant. On the flipside, we might have seen more interactions on a personal level with Jennifer Walters, Black Widow, Jessica Drew, Psylocke, and Silver Sable/Carol Danvers.
But wouldn't it be great if we finally see Spider-Woman vs The Black Cat(aka. Hardy vs Drew)!!!