I think there was this girl that Sandman thought was his daughter, who he ended up kidnapping(?), but she wasn't really. It was just a sign he was kind of going crazy.
And I guess if we're getting a "Sandgirl" then Ana Kravinoff probably has a decent chance of showing up as Kraven's daughter.
Also probably likely that Harry will be the Goblin so they can also have a teen Green Goblin.
I think it's going to be other way around. The Spiders are going to push aside every non-Spider member of Peter's supporting cast or the non-Spider heroes he traditionally interacts with (like Black Cat).
Can't have Muggles play a major part in things after all .