See I never cared much for the "sneaking out" thing myself (although I can certainly see why other fans liked it TBF). It's kind of like the "Superman trying to fool Lois Lane" thing, it just gets tedious after awhile.
I'd prefer that Aunt May find out early. Also Gwen, MJ, whomever his "best bud" ends up being, and perhaps Felicia and/or Harry later on.
...I don't know about Ned... in comics he was just kind of...there and in the movie this Ganke Ned guy blurted out that Peter was connected to Spider-Man to his whole class a day after learning it (I REALLY HATED THAT). So Harry of course should know, of course he starts off antagonistic, but gets over his dad issues and becomes a valuable ally.
Having seen a few episodes from the japanese emission, I don't think so for Anya. She becomes much friendlier to Peter, and she's a Spider-Man fangirl. Her main problem with Peter is that she feels he doesn't take things more seriously, always being late and missing homework. I imagine that knowing that he is Spider-Man would make her realize that there's a reason why he's been irresponsible about school.
I went with Ned because, as Frontier pointed points, Harry has the bad habit of becoming the second Green Goblin, and Peter really doesn't have that many friends (unless you count Johnny Storm or the later reformed Flash Thompson). If you avoid the super villain bit, it could work with Harry, too, though.
Eh, I guess, but it didn't really feel like the way it should with Ock, especially since he had every right to be ticked at Peter.
Maybe it'll become more pronounced once he becomes a Supervillain. It could just be Menville's performance that's throwing me off or that we just haven't seen much with this version.
I hope we have more Persona voice actors pop up as characters in the future. We already have P5's Akechi (Robbie Daymond) as Peter, Ryuji (Max Mittelman) as Harry, and P4's Rise (Laura Bailey) as Gwen.
Also, Peter demands pancakes!