As a broken record, I still wish they'd try harder with Anya Corazon. Not a Spider Girl, but as Arana, a spider character with her own mytho, independant from Spider Man.
With the right creative team, she has the potential to be a breakout character.
Or they could be bold like with Guardians of the Galaxy and go directly with a movie or a series. The public doesn't care if a character is A-list or D-list in the comics.