Edit: I just read that it is Sinister and Pierce & Reavers who are villains. I had asked what characters could be in place of the Hulk. I love the choice of Pierce and Reavers. They will translate well to film. I don't like spoilers for comics and movies, so I read very little about the content of future releases.
I've read that a blind Scott Summers would be good for Hawkeye's roll, and I agree. They would be totally free to hire whatever actor is right for the part. I also think an older and more serious Deadpool would work.