No, not a Geoff Johns esque, "my family died", kinda thing, but think about it. He thought that the most powerful mutants would rule the world, but instead it's been taken over by "slaves".
It's like imagine preparing your estate for your most gifted children, only to return and see it being run into the ground by the janitor that you should have fired for always being late.
Surely more can be done with this angle to make Apocalypse more than just a youthful indiscretion of Darkseid and Ares.