But if we believe the few piece of information released so far, this hybrid movie/mini-series will be ignoring all of that.
Not really ignoring it so much as it just not being on the Royal Family's radar, who are intentionally not getting involved with the events on Earth and shielding themselves from the public eye as much as possible. This would explain not getting involved with events like the Chitauri Invasion, Age of Ultron, or whatever is going down in The Defenders. And, who knows, maybe the Inhumans storyline on Agents of SHIELD will be resolved by the time The Inhumans hits IMAX cinemas.
The only legitimate question will be how much involvement will the Royal Family have in Infinity War/Avengers 5. They COULD be included, if this IMAX Theatrical Premiere is any indication of a desire to make this the one series that becomes involved with the movies. Is that possible? Yes. Is it likely? Hell no. Feige wouldn't have been speaking about Inhumans in that way if there was any plan for them factoring into Infinity War. Which, IMO, is bordering on being a plot hole.Unless they're not aware of Thanos' threat and ignoring something that directly affects their very existence is extremely out of character. These are the problems with the movies not connecting to the shows, specifically THIS show, which seems like it would only work as a movie because of how significant the Inhumans' place are in the broader Marvel Universe.