I really thing that Blade could be one of the easiest ones.
It could be a 2D Castlevania, a more stealth tipe of game, a monster hunter one, a Full Horror one, a God of War with fast action or a Dark Souls/Nioh kind of game.
To say something a bit more crazy, i thing that Stephen Strange could work very well in a turn based JRPG by Atlus:
Anyone has played a Raidou Kuzunoha?. In that games you play as a demon summoner who solves crimes related to supernatural beings with the help of the demons from all kind of mytologies .You collect them in dungeons who are something like an alternative universe, they could be based in Asgard or Olympus. In the Shin Megami Tensei lore Thor, Odin and Ghost Rider are already monsters you can capture.
There is also a simple morality aligment, evil, neutral or good, each one associated to a different ending and to other character. For the moral companions for example i will use Daimon hellstrom as the Evil route, Enchantress as neutral route and Brother Voodo or Wiccan in the good route.