Bit confused with this issue as I'm not that familiar with Fantomex and "The World" so I'm not sure exactly how I feel about this issue.
-We open up with Sabretooth massacring the Inhumans until Karnak stops him. Karnak meets with Medusa and they converse. We then realize that Jean and The Cuckoos are secluded with Karnak and are keeping him mentally incapacitated.
-Jean scolds whoever used Sabretooth to piss Karnak off and it turns out to be Irma. Jean doesn't want Karnak to be out for blood once their game is over and The Cuckoos don't think it'll matter.
-Cut to Fantomex inside "The World". He's supposed to be aiding the girls but has ulterior motives.
-As Fantomex fights robots in "The World", Karnak fights the main XMEN teams including Banshee and Armor.
-Irma slips again and shows Karnak where The Cuckoos were created. The other sisters are mad about this.
-Fantomex seems to have found an old "Someday Corporation" facility and is revealed to be looking for the virus Someday used to weaponize mutants.
-Irma loses her connections with Fantomex and it's revealed she knew he was doing other "work". The rest discuss how this jeopardizes their mission. Meanwhile, Karnak finds the "flaw" in the girls plan.
-Fantomex plans to use the virus to take over "The World."