Has it been said what issue this is ending with? It's been my understanding that Mignola is wrapping things up here and moving on from the Hellboy universe.
I'm relatively new to Hellboy, reading through the Library editions for the first time and getting close to the end, and was hoping I could jump into current BPRD once I finish (Plague of Frogs seems to either be out of print or in between printings and Hell on Earth only just started HC collections, which would be my preferred format) and it would be a bummer to see the series end right away.