So from what I gathered, in no order:
Slott has left the door open for a lot of bad guys cloned from being dead to be in the alive or dissolved so some can be used again
Kaine is clearly still sick and dying (hoping he gets cured), out to pursue Ben knowing he's too smart to be gone
The proto clone Otto and Ben worked on wasn't shown, Otto is presumed dead by the cast
Lizard turned his wife and son into half lizard half human terrifying specimens who seem to be roughly full lizard brain when it comes to speech
Ben Reilly is going to New York
He may or may not have orchestrated an attack in a New U employee to gain her trust by saving her so he gets money from her
Kingpin gives spidey the location and details of Osborn on a USB drive as his favor owed to spidey
So this just serves as a set up for the next spidey arc and the Ben title.