It's been a while since I've posted here but this thread brought my interest enough to say something.
If it's true that Spider-Man is doomed to never have his marriage to MJ restored, then it's a little wierd to think that we are past his greatest possible relationship status quo ever in core continuity and we can never get that back.
I can't think of a way to have a future relationship meet or exceed what that relationship was given the fact that he can no longer tie the knot with anyone. So it's kind of awkward and disappointing that Marvel are willing to settle for second place romances from here on out....