Pretty simple, really. Who are the most skilled combatants in hand-to-hand combat within the Marvel Universe? Who are the characters who know martial arts, and know it well, that they can dominate opponents, even ones stronger than them, with their skill and expertise?
For the record, this refers to actual skill, not just people who have super strength and get by because they can hit super hard. Hulk may be a destructive force of nature, but few would call him a skilled martial artist.
Anyways, the ones that come to mind:
Shang-Chi
Iron Fist
Captain America
Taskmaster
X-23
Cable
Daredevil
Elektra
Karnak
Cyclops
Black Widow
Hawkeye
Mockingbird
Who else is of note?