I really enjoyed this issue - it was a bombastic conclusion to consistently great run by Kelly and McGuiness on this book. I enjoyed the characterization of both Spidey and Deadpool in this issue (especially Deadpool) and I really liked the reflective tone this issue took. I do wonder, though, how and why Deadpool temporarily appeared like he was wearing Spider-Man's suit when he dropped Itsy Bitsy into Peter's Plasma Breeder Reactor. Seems like a plot hole there.
Overall though, I think it is evident I enjoyed this whole run, especially the conclusion. I look forward to what comes next (after the coming guest story) and who the new main writers will be. It will be hard to live up to Kelly and McGuiness, but I'd love to see them try!