Yeah, outside TV he's mainly done some romantic comedy and faith films. Apparentally he's one of Nolan North's favorites for the role.
Nathan Fillion seems to be a fan favorite, but he's almost as old as the older Nathan in UC4's epilogue.
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Nathan Fillion would be great if the people behind the movie also have a time mechine. But when you're going back, do you take him off the set of Two Guys, a Girl, and a Pizza Place or do you take Ryan Reynolds? And if you take Reynolds, what was the point of the time mechine?
Then again, if you have a time mechine you just get early '90s Bruce Campbell.
Right now I'm not really sure you can do an Uncharted movie. I mean, no one really gives a shit about seeing a movie with that character or based on that series. Only reason to really do an Uncharted movie is if you wanted to see a certain type of actor doing wisecracking Indiana Jones. Right now I don't really think there is any actor I'd really want to see doing that.