Personally I see it as follows
Captain America: starring Steve Rogers back in the role and the path to clearing his name
The Falcon: starring Sam Wilson, though I think this may be a 2018 release as I think Sam will be the hero who retires after Secret Empire
Captain Marvel: they'll give Carol yet another try, hoping the her movie appearances will inject some life, this series may explore her past more, maybe have her regain her memories and emotions
Iron Man: starring a returned Tony Stark
Maybe and Iron Heart ongoing or mini, she may just be part of the Iron Man supporting cast
Amazing Spider-Man, with Spectacular and maybe some other satelite books
I think Miles Morales will give the Arachnid code name a tryout, if it's not successful, they'll go back to Spider-Man, with the Ultimate legacy numbering
Runaways is new it's not going anywhere
Secret Warriors, Black Bolt, and Royals will probably all be folded in a unified Inhumans book
U.S.Avengers will probably finish up and lead to a New Warriors and New Mutants series
Deadpool business as usual, probably fewer minis
Avengers: back with a more all-star and movie like lineup
Thor: Jason AAron will finish up his story and it's back to Thor, with Jane Foster probably dead
Not sure what will become of Doom, Johnny and Ben, as the remnants of the FF franchise, they'll probably float around as supporting characters till a proper FF revival is done
Hulk: back with Banner, with a de-hulked Cho maybe in the supporting cast
Hulk will probably revert to She-hulk with legacy numbering
Venom will go on, especially with a movie upcoming
Scarlet Spider and RYV probably finish up at issue 12
Spider-Gwen and Gwenpoole will continue, though I'm sure Marvel will watch to see if the characters were both just passing fads
Spider-Man/Deadpool will probably continue and be it's own thing, not beholden to what's going in the rest of the line
Ms Marvel will probably join Squirrel Girl, and Moon Girl as books that occupy their own little corner of the mu
Daredevil, Luke Cage, Iron Fist, Jessica Jones, Punisher, and Defenders will probably all get some legacy numbering
Doctor Strange, Black Panther, Guardians of the Galaxy will get some legacy numbering and no more spin-offs
America, Nick Fury, and Thanos probably headed for cancellation land
Champions with some Legacy numbering, Black Widow joining the cast, and most of the new characters, since they seem to want to brand Champions as the catchall for the young characters.
Hawkeye maybe relaunched with legacy numbering and a more equal partnership and characterization, less Clint Barton incompetent boob and Kate Bishop manic pixie dreamgirl
X-Men Blue,Gold, and Astonishing will probably eventually be pared down to Uncanny and Adjectiveless with legacy numbering, wait for 2018 for that though
All-New Wolverine, Old Man Logan, and Weapon will depend on probably the 2018 return of Wolverine, Probably end up with a Wolverine book, X-23, and X-Force, all with legacy numbering.
Generation X will probably be replaced by the above mentioned New Mutants book, and Jean Grey, Iceman, and Cable will probably get 12-18 issue runs
As for down the line I'd say we'll see a Cloak and Dagger book, Moon Knight, and something with the horror characters.